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Neuronal NLRP3 is a parkin substrate that drives neurodegeneration in Parkinson's disease
Authors: Nikhil Panicker, Tae-In Kam, Hu Wang, Stewart Neifert, Shih-Ching Chou, Manoj Kumar, Saurav Brahmachari, Aanishaa Jhaldiyal, Jared T Hinkle, Fatih Akkentli, Xiaobo Mao, Enquan Xu, Senthilkumar S Karuppagounder, Eric T Hsu, Sung-Ung Kang, Olga Pletnikova, Juan Troncoso, Valina L Dawson, Ted M Dawson
Journal: Neuron
PubMed ID: 35654037
Doi: 10.1016/j.neuron.2022.05.009
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Lipases secreted by a gut bacterium inhibit arbovirus transmission in mosquitoes
Authors: Xi Yu, Liangqin Tong, Liming Zhang, Yun Yang, Xiaoping Xiao, Yibin Zhu, Penghua Wang, Gong Cheng
Journal: PLoS Pathog
PubMed ID: 35679229
Doi: 10.1371/journal.ppat.1010552
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α-Synuclein Impacts on Intrinsic Neuronal Network Activity Through Reduced Levels of Cyclic AMP and Diminished Numbers of Active Presynaptic Terminals
Authors: Kristian Leite, Pretty Garg, F Paul Spitzner, Sofia Guerin Darvas, Mathias Bähr, Viola Priesemann, Sebastian Kügler
Journal: Front Mol Neurosci
PubMed ID: 35721317
Doi: 10.3389/fnmol.2022.868790
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Cell-Penetrating Peptide TAT-HuR-HNS3 Suppresses Proinflammatory Gene Expression via Competitively Blocking Interaction of HuR with Its Partners
Authors: Ke Wang, Haibin Tong, Yitian Gao, Lan Xia, Xin Jin, Xiaoxue Li, Xianlu Zeng, Istvan Boldogh, Yueshuang Ke, Xueqing Ba
Journal: J Immunol
PubMed ID: 35444028
Doi: 10.4049/jimmunol.2200002
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Quadrivalent mosaic HexaPro-bearing nanoparticle vaccine protects against infection of SARS-CoV-2 variants
Authors: Yin-Feng Kang , Cong Sun , Jing Sun , Chu Xie , Zhen Zhuang , Hui-Qin Xu , Zheng Liu , Yi-Hao Liu , Sui Peng , Run-Yu Yuan , Jin-Cun Zhao , Mu-Sheng Zeng
Journal: Nat Commun
PubMed ID: 35562337
Doi: 10.1038/s41467-022-30222-w
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LPS Response Is Impaired by Urban Fine Particulate Matter
Authors: Natália de Souza Xavier Costa, Gabriel Ribeiro Júnior, Adair Aparecida Dos Santos Alemany, Luciano Belotti, Marcela Frota Cavalcante, Susan Ribeiro, Mariana Matera Veras, Esper Georges Kallás, Paulo Hilário Nascimento Saldiva, Marisa Dolhnikoff, Luiz Fernando Ferraz da Silva
Journal: Int J Mol Sci
PubMed ID: 35409273
Doi: 10.3390/ijms23073913
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Microglial NF-κB drives tau spreading and toxicity in a mouse model of tauopathy
Authors: Chao Wang, Li Fan, Rabia R Khawaja, Bangyan Liu, Lihong Zhan, Lay Kodama, Marcus Chin, Yaqiao Li, David Le, Yungui Zhou, Carlo Condello, Lea T Grinberg, William W Seeley, Bruce L Miller, Sue-Ann Mok, Jason E Gestwicki, Ana Maria Cuervo, Wenjie Luo, Li Gan
Journal: Nat Commun
PubMed ID: 35413950
Doi: 10.1038/s41467-022-29552-6
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Phage Therapy Potentiates Second-Line Antibiotic Treatment against Pneumonic Plague
Authors: Yaron Vagima, David Gur, Moshe Aftalion, Sarit Moses, Yinon Levy, Arik Makovitzki, Tzvi Holtzman, Ziv Oren, Yaniv Segula, Ella Fatelevich, Avital Tidhar, Ayelet Zauberman, Shahar Rotem, Emanuelle Mamroud, Ida Steinberger-Levy
Journal: Viruses
PubMed ID: 35458417
Doi: 10.3390/v14040688
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Targeting lipophagy in macrophages improves repair in multiple sclerosis
Authors: Mansour Haidar, Melanie Loix, Sam Vanherle, Tess Dierckx, Tim Vangansewinkel, Pascal Gervois, Esther Wolfs, Ivo Lambrichts, Jeroen F J Bogie, Jerome J A Hendriks
Journal: Autophagy
PubMed ID: 35282773
Doi: 10.1080/15548627.2022.2047343
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Distinct effects of treatment with two different interferon-alpha subtypes on HIV-1-associated T-cell activation and dysfunction in humanized mice
Authors: Saurav S Rout, Yunyun Di, Ulf Dittmer, Kathrin Sutter, Kerry J Lavender
Journal: AIDS
PubMed ID: 35084382
Doi: 10.1097/QAD.0000000000003111
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